Table 3.
Distribution of Avian bornavirus (ABV) antigen in tissues of 10 ABV RNA–positive psittacine birds with (birds 1–3, 6–9) and without (birds 4, 5, 10) clinicopathologic evidence of proventricular dilatation disease (PDD) from 1 aviary in comparison to 5 ABV RNA–negative psittacine birds without signs of PDD from other aviaries (birds 11–15).*
| Case no. | Brainstem | Cerebellum | Cerebrum | Spinal cord | Spinal ganglion | Crop | Proventriculus | Ventriculus | Duodenum | Pancreas | Heart | Adrenal gland | Eye | Kidney |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ++ | – | + | ND | ND | + | + | + | – | – | – | ND | + | – |
| 2 | ++ | + | ++ | ND | ND | ND | + | + | ND | ND | – | ND | ND | – |
| 3 | ++ | – | ++ | ++ | + | – | – | – | – | – | – | ND | – | + |
| 4 | – | – | – | ND | ND | – | – | – | – | +cyto | – | ND | – | – |
| 5 | +++ | +++ | +++ | ND | ND | +++ | +++ | +++ | ++ | ++ | ++ | ND | ND | +++ |
| 6 | ++ | ++ | ++ | ND | ND | ++ | + | + | ND | ND | – | ND | – | – |
| 7 | +++ | +++ | +++ | ND | ND | + | ++ | + | ++ | +cyto | + | + | ND | – |
| 8 | ++ | + | +++ | + | + | + | +cyto | + | – | – | – | ND | – | – |
| 9 | +++ | + | ++ | + | + | ND | ++ | +++ | ++ | +cyto | – | ND | ND | – |
| 10 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ |
| 11 | – | – | – | ND | ND | – | +cyto | – | – | +cyto | – | – | – | – |
| 12 | – | – | – | ND | ND | – | +cyto | – | – | +cyto | – | – | – | – |
| 13 | – | – | – | ND | ND | – | – | – | – | – | – | – | – | – |
| 14 | – | – | – | ND | ND | – | – | – | – | – | – | – | – | – |
| 15 | – | – | – | ND | ND | – | – | – | – | – | – | – | – | – |
*
Subjective grading scheme: – = no immunoreactivity; + = mild nuclear and cytoplasmic immunoreactivity; ++ = moderate nuclear and cytoplasmic immunoreactivity; +++ = marked nuclear and cytoplasmic immunoreactivity; +cyto = cytoplasmic immunoreactivity only; ND = not done.