Table 1.
Top 0.5% essential genes according to the second best scoring hairpin in GIST882 and GIST-T1 (n=56 for each). Genes in bold font (upper fields) scored top 0.5% in the gene distribution in GIST lines but not in 12 non-GIST reference cancer cell lines of various lineages (described by Luo et al.15). Genes in regular font (lower fields) scored top 0.5% in both GIST and the 12 non-GIST reference set.
| GIST882 and GIST-T1 | GIST882 only | GIST-T1 only |
|---|---|---|
| CDC37 | UBC | PSMC4 |
| POLE | DYNC1H1 | EFTUD2 |
| RPS18 | VCP | PSMA2 |
| PSMA3 | HNRPK | PRPF3 |
| SFRS3 | PABPN1 | NCBP2 |
| EIF3S10 | SNRPD1 | ABCB7 |
| RPS13 | PSMC1 | EIF3S3 |
| RPS29 | FRAP1 | ATPBD1C |
| RPL23A | AFG3L2 | RPAP1 |
| PSMB2 | LOC375133 | RBM8A |
| RPL5 | PSMA6 | DDX48 |
| RPS9 | EIF3S5 | RNPS1 |
| RPS17 | TSG101 | COPS2 |
| RPL31 | PTPRCAP | RPS10 |
| ARCN1 | TUBB | MLXIP |
| PHB2 | RPS19 | ATP1A1 |
| RPS7 | KARS | POLR2F |
| RPS27A | SNRPD2 | RUVBL2 |
| RPS8 | PSMA1 | NUP205 |
| RPS15A | RPS14 | MKI67IP |
| PSMD1 | HNRPU | RAN |
| U2AF2 | RPS6 | RPS3A |
| CHD4 | RPS3 | RPS4X |
| AQR | ASCC3L1 | RPS11 |
| NHP2L1 | RPL34 | RPL7 |
| NDUFA4L2 | RPL6 | |
| RPSA | EIF5B | |
| USP39 | EIF2S2 | |
| PHB | SNRPE | |
| EIF1AX | HSPE1 | |
| TPR | U2AF1 | |