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Mechanism of catalysis of deglutathionylation by GRX. A glutathionylated protein (PS-SG) is restored by the action of GRX. GRX operates by a monothiol mechanism in the process of deglutathionylation. The glutathione (GSH) is transferred from the protein to GRX. A second GSH molecule restores the normal GRX active site structure with the production of GSSG. The GSSG produced is reduced to GSH by the action of GR which uses NADPH as a cofactor.
