FIGURE 2:

The distribution of interpeak times within individual cells varies from one cell to another. (A) Schematic illustrating variation within cells and between cells. (B) Nuclear localization traces and (C) interpeak time distributions of three cells (selected from 199 total across two experiments) monitored for 20 h upon stimulation with 10 ng/ml TNF. (D) Mean interpeak time for each cell plotted against CV. (E) Mean and SDs of interpeak time for each individual cell plotted together with the distribution that would be expected without intercellular variability (black). (F) Ratio of variance between cells to variance within cells (F statistic), as determined using bootstrap analysis.