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Effects of nalbuphine (1.0 mg/kg) and naltrexone (0.1 mg/kg) on ICSS before and during chronic morphine treatment. All points show mean ± SEM for 6 rats (panels a-d) or 5 rats (panels e,f). For description of axes and symbols, please refer to figures 1 and 2. Filled points indicate significantly different from “Vehicle.” Asterisks indicate significantly different from “0.1 NLTX + 1.0 nalbuphine”.
