. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Toxicol Pathol. 2014 Oct 27;43(1):107–114. doi: 10.1177/0192623314556516

Table 1. Species differences in chemically induced lung tumor response (with clear or some evidence of carcinogenicity) in NTP chronic bioassays^*.

Animal species and sex	Studies that are carcinogenic including all organs, n=67; %(n)	Studies with lung tumor response, n=67; %(n)
Rat Male	69% (46)	24% (16)
Rat Female	70% (47)	24% (16)
Mouse Male	63% (42)	60% (40)
Mouse Female	76% (51)	64% (43)

In a survey of 580 NTP chronic bioassays, there were only 67 studies where the same chemical was tested in both mice and rats and at least one species had a lung tumor response.

Table 1. Species differences in chemically induced lung tumor response (with clear or some evidence of carcinogenicity) in NTP chronic bioassays*.

Table 1. Species differences in chemically induced lung tumor response (with clear or some evidence of carcinogenicity) in NTP chronic bioassays^*.