Table 1. Species differences in chemically induced lung tumor response (with clear or some evidence of carcinogenicity) in NTP chronic bioassays*.
Animal species and sex | Studies that are carcinogenic including all organs, n=67; %(n) |
Studies with lung tumor response, n=67; %(n) |
---|---|---|
Rat Male | 69% (46) | 24% (16) |
Rat Female | 70% (47) | 24% (16) |
Mouse Male | 63% (42) | 60% (40) |
Mouse Female | 76% (51) | 64% (43) |
In a survey of 580 NTP chronic bioassays, there were only 67 studies where the same chemical was tested in both mice and rats and at least one species had a lung tumor response.