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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Nat Genet. 2015 Jan 12;47(2):126–131. doi: 10.1038/ng.3186

Table 1.

Accumulation of different classes of mutation in exomes of West African compared to exomes of European ancestry

R: Relative accumulation of mutations R2: Relative accumulation of homozygous mutations
Data set West Africans Europeans R(synonymous) R(All non-synonymous) R(Benign) R(Possibly damaging) R(Probably damaging) R2(synonymous) R2 (All non-synonymous) R2 (Benign) R2 (Possibly damaging) R2 (Probably damaging)
24 deep genomes 4 4 1.022
(0.012)		 1.008
(0.015)		 1.002
(0.018)		 1.007
(0.040)		 1.031
(0.038)		 0.652
(0.014)		 0.629
(0.019)		 0.628
(0.021)		 0.602
(0.043)		 0.660
(0.047)
Celera exomes 15 20 0.982
(0.011)		 1.010
(0.019)		 1.011
(0.022)		 1.019
(0.043)		 0.992
(0.039)		 0.610
(0.011)		 0.586
(0.047)		 0.583
(0.021)		 0.616
(0.053)		 0.586
(0.047)
1KG exomes 88 85 1.019
(0.010)		 0.994
(0.012)		 0.999
(0.015)		 0.955
(0.028)		 1.011
(0.026)		 0.655
(0.012)		 0.656
(0.014)		 0.639
(0.018)		 0.599
(0.032)		 0.642
(0.032)
ESP exomes 1,088 1,351 1.004
(0.009)		 1.001
(0.011)		 0.993
(0.013)		 1.001
(0.021)		 1.037
(0.029)		 0.605
(0.010)		 0.608
(0.011)		 0.598
(0.015)		 0.578
(0.025)		 0.630
(0.034)

Notes: ±1 standard errors are obtained from a Weighted Block Jackknife with 100 equally sized blocks. For the whole genomes, Yoruba+Mandenka represent West Africans, and French+Sardinian represent Europeans. For the 1000 Genomes Data (1KG), YRI represent West Africans and CEU represent Europeans. The Celera and ESP analyses represent people of West African ancestry using African Americans.