Table 3.

Correlation of TGF-βRII and pSmad2 expression with invasiveness of breast cancer, Shanghai Breast Cancer Study, Phase II

	TGF-βRII intensity				TGFβ-RII subcellular pattern			pSmad2 intensity
	0–1	2	3	P	1c	2d	P	0–1	2	3	P
Adjacent normal breast tissue
Number	24	212	570		664	142		312	231	261
%	3.0	26.3	70.7		82.4	17.6		38.8	28.7	32.5
Non-invasive, in situ carcinomaa
Number	3	28	59		24	66		17	34	39
%	3.3	31.1	65.6		26.7	73.3		18.9	37.8	43.3
In situ with invasive carcinomaa
In situ component
Number	18	93	220		120	211		61	109	161
%	5.4	28.1	66.5		36.3	63.8		18.4	32.9	48.6
Invasive component
Number	20	126	185		64	267		56	95	180
%	6.0	38.1	55.9		19.3	80.7		16.9	28.7	54.4
Invasive carcinomab
Number	74	275	275		95	529		124	182	318
%	11.9	44.1	44.1	<0.01	15.2	84.8	<0.01	19.9	29.2	51.1	<0.01

^aIncluding ISDC and ISLC

^bIncluding IDC, ILC and Others

^cMembranous predominant

^dCytoplasmic or membranous cytoplasmic