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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Obesity (Silver Spring). 2014 Dec 31;23(2):383–390. doi: 10.1002/oby.20969

Figure 5.

Figure 5

Obesity-induced hypertension is reversed by arginase inhibition or L-arginine administration. Mean arterial blood pressure (BP) is reduced in obese, but not lean, Zucker rats (ZR) by dietary L-arginine supplementation (L-Arg; 1% in drinking water for 6 days) (A and B) or arginase inhibition (intraperitoneal administration of S-(2-boronoethyl)-L-cysteine (BEC;55.6μg/h for 6 days) (C and D). Nω-hydroxy-nor-L-arginine (OHNA;50 mg/kg, ip, daily for 6 days) reduces mean arterial BP in obese, but not lean, ZR (E). Results are means ± SEM (n=5–6). *Statistically significant effect of obesity.