Figure 2. Model-predicted and observed statistics on age-specific incidence (a), mortality (b), and stage distribution of breast cancer (c) in Japan and the United States. A population of 100 000 women was traced from age 0 to 100 years. Observed statistics on incidence^a peaked (154.5 per 100 000 women) in those age aged 45–49 years in Japan, whereas the incidence increased continuously from age 45 and peaked (433.1 per 100 000 women) in those aged 75–79 years in the United States. Observed statistics on mortality tended to increase with age in both Japan and the United States. Differences in mortality between Japan and the United States were marked in women aged 50 years or older. ^aExcluding carcinoma in situ.