Table 2. Top 20 compounds having an inverse association with amyotrophic lateral sclerosis (ALS).
| ATC-code | Compound name | P value | Odds-ratio (95% CI) |
Number of drug use patients (%) | ||
| Raw | FDR | ALS | Non-ALS | |||
| N02BA01 | Acetylsalicylate (Aspirin) | 0.0004 | 0.0173* | 0.67 (0.54, 0.84) | 111 (15.23%) | 1369 (18.78%) |
| R06AA02 | Diphenhydramine | 0.0013 | 0.0323* | 0.68 (0.54, 0.86) | 94 (12.89%) | 1150 (15.78%) |
| M01AG01 | Mefenamic Acid | 0.0016 | 0.0358* | 0.77 (0.66, 0.91) | 384 (52.67%) | 4134 (56.71%) |
| R05DB24 | Tipepidine Hibenzate | 0.0027 | 0.0517 | 0.66 (0.50, 0.87) | 64 (8.78%) | 857 (11.76%) |
| A02BA01 | Cimetidine | 0.0029 | 0.0521 | 0.77 (0.65, 0.92) | 234 (32.1%) | 2564 (35.17%) |
| R03CC03 | Terbutaline Sulfate | 0.0038 | 0.0630 | 0.62 (0.45, 0.86) | 42 (5.76%) | 599 (8.22%) |
| R03DA05 | Aminophylline | 0.0044 | 0.0682 | 0.73 (0.59, 0.91) | 124 (17.01%) | 1383 (18.97%) |
| C09AA02 | Enalapril Maleate | 0.0052 | 0.0726 | 0.64 (0.46, 0.87) | 46 (6.31%) | 643 (8.82%) |
| R06AX15 | Mebhydroline | 0.0059 | 0.0748 | 0.73 (0.58, 0.91) | 97 (13.31%) | 1155 (15.84%) |
| R06AB04 | Chlorpheniramine Mal | 0.0058 | 0.0748 | 0.75 (0.61, 0.92) | 128 (17.56%) | 1455 (19.96%) |
| C09AA01 | Captopril | 0.0070 | 0.0810 | 0.63 (0.45, 0.88) | 41 (5.62%) | 560 (7.68%) |
| R06AA07 | Piprinhydrinate | 0.0080 | 0.0862 | 0.70 (0.54, 0.91) | 70 (9.6%) | 868 (11.91%) |
| A02AF02 | Simethicone Emulsion | 0.0086 | 0.0862 | 0.77 (0.63, 0.94) | 562 (77.09%) | 5762 (79.04%) |
| N02BE01 | Acetaminophen | 0.0108 | 0.0992 | 0.76 (0.61, 0.94) | 605 (82.99%) | 6183 (84.81%) |
| R06AX12 | Terfenadine | 0.0120 | 0.1068 | 0.78 (0.65, 0.95) | 153 (20.99%) | 1716 (23.54%) |
| J01CA04 | Amoxycillin | 0.0127 | 0.1091 | 0.82 (0.70, 0.96) | 392 (53.77%) | 4099 (56.23%) |
| R05DB01 | Benzonatate | 0.0136 | 0.1097 | 0.67 (0.49, 0.92) | 46 (6.31%) | 591 (8.11%) |
| G04BX06 | Phenazopyridine | 0.0145 | 0.1104 | 0.65 (0.46, 0.92) | 38 (5.21%) | 524 (7.19%) |
| R05CA10 | Glycyrrhiza Fluid Ext | 0.0173 | 0.1214 | 0.74 (0.58, 0.95) | 83 (11.39%) | 973 (13.35%) |
| C01DA08 | Isosorbide Dinitrate | 0.0190 | 0.1294 | 0.63 (0.43, 0.93) | 30 (4.12%) | 413 (5.67%) |
ATC-code, Anatomical Therapeutic Chemical code; CI, confidence interval; FDR, false discovery rate.
*FDR-adjusted P < 0.05.