Table 3. Association between aspirin, diphenhydramine, and mefenamic acid use and amyotrophic lateral sclerosis (ALS) risk.

Variable	Unadjusted analysis		Adjusted analysis
	Odds ratio (95% CI)	P value	Odds ratio (95% CI)	P value
Aspirina	0.67 (0.54–0.84)	<0.001	0.69 (0.56–0.87)	0.001
Diphenhydraminea	0.68 (0.54–0.86)	0.001	0.87 (0.72–1.04)	0.132
Mefenamic Acida	0.77 (0.66–0.91)	0.002	0.96 (0.80–1.16)	0.695
Steroid (cDDD)
0	1.00		1.00
1–29	1.17 (0.98–1.39)	0.078	1.25 (1.04–1.49)	0.015
≥30	2.11 (1.70–2.62)	<0.001	2.38 (1.90–2.99)	<0.001

cDDD, cumulative defined daily dose; CI, confidence interval.

^aAny use vs. no use.