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. 2014 Jun 28;23(1):85–94. doi: 10.1016/j.jsps.2014.06.005

Table 7.

Degradation rate constant (Kobs), half-life (t1/2), t90 and R2 values for gatifloxacin in solution.

Temperature (K) Kobs (h−1) a t1/2 (h)b t90 (h)c R2 for pseudo-first order plots
In 1 N HCl
313 (40 °C) 0.126 5.49 0.83 0.9917
323 (50 °C) 0.161 4.30 0.65 0.9989
333 (60 °C) 0.203 3.42 0.52 0.9930
343 (70 °C) 0.238 2.91 0.44 0.9986
353 (80 °C) 0.330 2.11 0.32 0.9964



In 1 N NaOH
313 (40 °C) 0.081 8.55 1.30 0.9927
323 (50 °C) 0.103 6.71 1.02 0.9921
333 (60 °C) 0.124 5.62 0.85 0.9938
343 (70 °C) 0.140 4.93 0.75 0.9987
353 (80 °C) 0.151 4.58 0.70 0.9971
a

Degradation rate constant.

b

Half-life.

c

Time for 90% potency left.