Table 7.
Degradation rate constant (Kobs), half-life (t1/2), t90 and R2 values for gatifloxacin in solution.
Temperature (K) | Kobs (h−1) a | t1/2 (h)b | t90 (h)c | R2 for pseudo-first order plots |
---|---|---|---|---|
In 1 N HCl | ||||
313 (40 °C) | 0.126 | 5.49 | 0.83 | 0.9917 |
323 (50 °C) | 0.161 | 4.30 | 0.65 | 0.9989 |
333 (60 °C) | 0.203 | 3.42 | 0.52 | 0.9930 |
343 (70 °C) | 0.238 | 2.91 | 0.44 | 0.9986 |
353 (80 °C) | 0.330 | 2.11 | 0.32 | 0.9964 |
In 1 N NaOH | ||||
313 (40 °C) | 0.081 | 8.55 | 1.30 | 0.9927 |
323 (50 °C) | 0.103 | 6.71 | 1.02 | 0.9921 |
333 (60 °C) | 0.124 | 5.62 | 0.85 | 0.9938 |
343 (70 °C) | 0.140 | 4.93 | 0.75 | 0.9987 |
353 (80 °C) | 0.151 | 4.58 | 0.70 | 0.9971 |
Degradation rate constant.
Half-life.
Time for 90% potency left.