Table 2.
Mixture design specifications.
| Response name |
Goal |
Lower limit |
Upper limit |
|---|---|---|---|
| 2.A. Response name, goal and limits for mixture design | |||
| Dissolution | Maximize | 0 | 0.75 |
| Hardness | Match target | 6 | 12 |
| Assay | Match target | 122.2 | 137.8 |
| Disintegration | Match target | 0 | 5 |
| Angle of repose | Minimize | . | . |
| Name |
Role |
Changes |
Values |
|
|---|---|---|---|---|
| 2.B. Factor name, role, changes and values for mixture design | ||||
| Avicel | Mixture | Easy | 0.2 | 0.5 |
| Silicon Dioxide | Mixture | Easy | 0.001 | 0.005 |
| Stearic Acid | Mixture | Easy | 0.01 | 0.03 |
| Magnesium Stearate | Mixture | Easy | 0.0025 | 0.05 |
| Dicalcium Phosphate | Mixture | Easy | 0 | 0.7865 |