Table 1.
The composition of the tested formulations (expressed in grams per formulation) and the entrapment efficiency of the drug into proniosomes.
| Formulation | Surfactant system⁎ | Ethanol | Aqueous phase⁎⁎ | IPM | OA | PG | Entrapment efficiency (%) |
|---|---|---|---|---|---|---|---|
| P | 5 | 5 | 4 | – | – | – | 84.1 ± 0.3 |
| P/Lec. | 5 | 5 | 4 | – | – | – | 80.3 ± 0.3 |
| P/IPM | 5 | 5 | 4 | 1 | – | – | 87.7 ± 0.2 |
| P/OA | 5 | 5 | 4 | – | 1 | – | 88.2 ± 0.2 |
| P/OA-PG0.5 | 5 | 5 | 4 | – | 1 | 0.5 | 83.5 ± 1.5 |
| P/OA-PG1 | 5 | 5 | 4 | – | 1 | 1.0 | 84.5 ± 0.01 |
| P/OA-PG1.5 | 5 | 5 | 4 | – | 1 | 1.5 | 84.8 ± 0.2 |
⁎
The composition of the surfactant system in all formulations was Span 60 and cholesterol (4.5:0.5) except the formulation (P/lec) which contained Span 60, cholesterol and lecithin (3.5:0.5:1) respectively.
⁎⁎
The aqueous phase was 0.1% glycerol in water. The amount of the drug added to each formulation was 0.3 g.