Table 2.

Dofetilide drug interaction (common drugs).

•Cardiovascular drugs: Bepridil, Disopyramide, Dofetilide, Ibutilide, Procainamide, Sotalol, and other antiarrhythmic agents, Hydrochlorothiazide/Triamterene

•Antiobiotics/Antifungals/Antimalarials: Chloroquine, Halofantrine, Pentamidine Clarithromycin, Erythromycin, Sparfloxacin, Macrolides or Trimethoprim, alone or in combination with Sulfamethoxazole (CYP3A4 family), Ketoconazole

•Antipsychotic drugs: Chlorpromazine, Haloperidol, Mesoridazine, Thioridazine, Prochlorperazine or Trifluoperazine; Tricyclic antidepressants like Amitriptyline or Desipramine

•Pain meds/sedatives/antiemetics: Droperidol, Levomethadyl, Methadone, Cimetidine