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. 2014 Nov-Dec;66(6):640–648. doi: 10.1016/j.ihj.2013.12.021

Table 2.

Dofetilide drug interaction (common drugs).

  • Cardiovascular drugs: Bepridil, Disopyramide, Dofetilide, Ibutilide, Procainamide, Sotalol, and other antiarrhythmic agents, Hydrochlorothiazide/Triamterene

  • Antiobiotics/Antifungals/Antimalarials: Chloroquine, Halofantrine, Pentamidine Clarithromycin, Erythromycin, Sparfloxacin, Macrolides or Trimethoprim, alone or in combination with Sulfamethoxazole (CYP3A4 family), Ketoconazole

  • Antipsychotic drugs: Chlorpromazine, Haloperidol, Mesoridazine, Thioridazine, Prochlorperazine or Trifluoperazine; Tricyclic antidepressants like Amitriptyline or Desipramine

  • Pain meds/sedatives/antiemetics: Droperidol, Levomethadyl, Methadone, Cimetidine