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. 2014 Dec 10;7(6):665–671. doi: 10.1016/j.tranon.2014.09.007

Table 3.

Assessment of MVD and TVA. Assessment Was Done for the Tumors after Treatment. Results Are Shown as Fold Changes of Mean for Each Group in Comparison with Control. Arrows Indicate an Increase (Arrow Up) or Decrease (Arrow Down) of MVD or TVA in Treated Tumors versus Respective Controls

All Models SW872 UZLX-STS3 UZLX-STS5
MVD
 CD34
 DOX 1.0 ↑1.3 ↓1.1 ↓1.2
 PAZ ↓2.3⁎⁎## ↓2.0⁎⁎## ↓2.4⁎⁎## ↓3.3⁎#
 PAZ + DOX ↓2.3⁎⁎## ↓2.0⁎⁎## ↓2.4⁎⁎## ↓3.3⁎#
 VEGFR2
 DOX 1.0 1.0 1.0 ↓1.2
 PAZ ↓2.0 ⁎⁎## ↓2.0⁎⁎## ↓2.2⁎⁎## ↓2.0⁎#
 PAZ + DOX ↓2.0 ⁎⁎## ↓2.0⁎⁎## ↓2.2⁎⁎## ↓2.0⁎⁎##
TVA
 CD34
 DOX ↓1.2 ↑1.3 ↓1.7 ↓1.9
 PAZ ↓2.6⁎⁎## ↓1.7⁎# ↓3.4⁎# ↓4.2⁎#
 PAZ + DOX ↓2.9⁎⁎## ↓1.7⁎## ↓3.9⁎⁎## ↓4.7⁎#

Statistical significance was calculated using Mann-Whitney U test.

Compared to control: *P < .05, **P < .005; compared to DOX: #P < .05, ##P < .005.