Table 3.
Assessment of MVD and TVA. Assessment Was Done for the Tumors after Treatment. Results Are Shown as Fold Changes of Mean for Each Group in Comparison with Control. Arrows Indicate an Increase (Arrow Up) or Decrease (Arrow Down) of MVD or TVA in Treated Tumors versus Respective Controls
| All Models | SW872 | UZLX-STS3 | UZLX-STS5 | |
|---|---|---|---|---|
| MVD | ||||
| CD34 | ||||
| DOX | 1.0 | ↑1.3⁎ | ↓1.1 | ↓1.2 |
| PAZ | ↓2.3⁎⁎## | ↓2.0⁎⁎## | ↓2.4⁎⁎## | ↓3.3⁎# |
| PAZ + DOX | ↓2.3⁎⁎## | ↓2.0⁎⁎## | ↓2.4⁎⁎## | ↓3.3⁎# |
| VEGFR2 | ||||
| DOX | 1.0 | 1.0 | 1.0 | ↓1.2 |
| PAZ | ↓2.0 ⁎⁎## | ↓2.0⁎⁎## | ↓2.2⁎⁎## | ↓2.0⁎# |
| PAZ + DOX | ↓2.0 ⁎⁎## | ↓2.0⁎⁎## | ↓2.2⁎⁎## | ↓2.0⁎⁎## |
| TVA | ||||
| CD34 | ||||
| DOX | ↓1.2 | ↑1.3 | ↓1.7 | ↓1.9 |
| PAZ | ↓2.6⁎⁎## | ↓1.7⁎# | ↓3.4⁎# | ↓4.2⁎# |
| PAZ + DOX | ↓2.9⁎⁎## | ↓1.7⁎## | ↓3.9⁎⁎## | ↓4.7⁎# |
Statistical significance was calculated using Mann-Whitney U test.
Compared to control: *P < .05, **P < .005; compared to DOX: #P < .05, ##P < .005.