Table 3.

Supervised Analysis—Differentially Expressed miRNAs between Subcompartments

Liver Capsule versus Liver Parenchyma			Tumor Capsule versus TP			Liver Parenchyma versus TP			Liver Capsule versus Tumor Capsule
miRNA	FC	P Value	miRNA	FC	P Value	miRNA	FC	P Value	miRNA	FC	P Value
miR-19b	− 2.3	.03	miR-548c-3p	3.6	.02	miR-214	3.9	3.1E−6	miR-126	2.8	.002
let-7a	5.3	.03	miR-3201	− 2.1	.03	miR-199a-5p	2.8	2.7E−4	miR-99a	2.0	.003
miR-16-2*	− 3.1	.04	p-miR-1979*	− 1.8	.03	miR-199a-3p	3.8	2.9E−4	miR-146a	4.6	.003
miR-150	4.2	.05	p-miR-520 h	− 1.9	.04	miR-199b-3p	3.4	4.9E−4	let-7 g	3.4	.004
miR-548a-3p	− 2.5	.05	miR-150	3.4	.04	miR-125a-5p	2.7	.002	miR-27a	2.8	.01
miR-425	1.7	.05	miR-3128	− 2.3	.04	miR-342-3p	2.7	.003	miR-26a	2.5	.01
			p-miR-522	− 1.9	.04	miR-99b	1.9	.01	miR-150	3.7	.02
			miR-335	− 2.1	.04	miR-145	2.6	.01	miR-125b	2.8	.02
			miR-548e	6.0	.05	let-7e	2.7	.02	let-7i	3.5	.02
			let-7a	4.9	.05	miR-27a	2.6	.02	miR-100	2.2	.02
			p-miR-548i	2.4	.05	miR-195	2.9	.02	miR-155	5.0	.02
			miR-548a-3p	1.8	.05	miR-143	− 2.9	.02	miR-199a-5p	3.0	.03
			p-miR-520g	− 1.6	.05	miR-23a	2.8	.02	let-7c	2.8	.03
			miR-3148	− 2.6	.05	miR-150	− 2.8	.03	miR-768-5p	2.0	.03
						miR-146a	3.9	.03	miR-143	4.8	.03
						miR-155	2.8	.04	miR-23a	3.3	.03
									let-7a	3.1	.04
									miR-195	3.8	.04
									let-7f	3.4	.05
									miR-199a-3p	5.7	.05
									miR-342-3p	2.7	.05

MiRNA expression was compared case-wise for two compartments, respectively. Semiquantitative FC of miRNA expression and P value (paired t test) were calculated. miRNAs with FC ≥ 2 and P≤ .05 are displayed. MiRNA that were chosen for validation experiments are printed in bold. *miR-1979 is rather a fragment of Y RNA and no miRNA. p-mir, precursor-miRNA.