Table 2A.
A Summary of the Changes Induced by Bortezomib in MCL Cells
| Cells | Effect | Change Extent |
|---|---|---|
| NCEB cells | proliferation | IC50 = 5-2ng/ml |
| HBL-2 cells | proliferation | IC50 = 2.5-1.5ng/ml |
| SK-N-MC cells | proliferation | IC50 = 20ng/ml |
| keratinocytes | proliferation | IC50 = 4-7.5ng/ml |
| NCEB cells | TA | No effect |
| HBL-2 cells | TA | ↓45-80% |
| mononuclear cells isolated from MCL patients | TA | ↓0-80% |
| SK-N-MC cells | TA | ↓20-70% |
| keratinocytes | TA | ↓25-70% |
| NCEB cells | hTERT expression | ↓30% and 5% |
| HBL-2 cells | hTERT expression | ↓45% and 25% |
| NCEB cells | SP-1 Transcription factor binding to the hTERT promoter | ↓40% |
| HBL-2 cells | SP-1 Transcription factor binding to the hTERT promoter | ↓50% |
| HBL-2 cells | NFκB Transcription factor binding to the hTERT promoter | ↓65% |
| HBL-2 cells | c-Myc Transcription factor binding to the hTERT promoter | ↓58% |
| NCEB cells | Phosphorylation of telomerase | ↓40% |
| HBL-2 cells | Phosphorylation of telomerase | ↓60% |
| NCEB cells | Phosphorylation of AKT | ↓20% |
| HBL-2 cells | Phosphorylation of AKT | ↓35% |
| NCEB cells | Phosphorylation of PKCα | ↓50% |
| HBL-2 cells | Phosphorylation of PKCα | ↓50% |
| mononuclear cells isolated from MCL patients | Phosphorylation of PKCα | ↓60% |
| NCEB cells | Expression of PP2A | No change |
| NCEB cells | Expression of PP2A | A slight increase |