Table 2.
Serotonin release by anti-inflammatory drugs and antidepressants.
| A | ||
|---|---|---|
| 10 min | 60 min | |
| control | 10.1 ± 2.4 (14)− | 5.1 ± 1.2 (12)− |
|
| ||
| citalopram | 29.4± 5.4 (9)* | 32.6±9.5 (8)** |
|
| ||
| ibuprofen | 22.2±3.7 (9) ns | 10.4± 1.9 (9) ns |
|
| ||
| indomethacin | 34.3±7.0 (9) ns | 25.7±6.7 (9)* |
|
| ||
| paroxetine | 45.9±9.2 (10)*** | 50.5±9.5 (7)*** |
|
| ||
| sertraline | 38.1 ± 6.4 (10)** | 30.1 ± 8.6 (10)** |
| B | ||
|---|---|---|
| 10 min | 60 min | |
| control + Ca2+ | 25.7± 8.4(9)− | 16.1 ±4.9(7)− |
|
| ||
| citalopram + Ca2+ | 26.6±3.1 (4) ns | 14.6± 1.8 (3) ns |
|
| ||
| ibuprofen + Ca2+ | 59.1 ±22.5 (4)* | 31.1 ± 13.1 (4) ns |
|
| ||
| indomethacin + Ca2+ | 28.7±3.4 (4) ns | 14.6±2.0 (4) ns |
|
| ||
| paroxetine + Ca2+ | 96.7±38 (4)*** | 34.8± 8.7 (2) ns |
|
| ||
| sertraline + Ca2+ | 39.1 ±8.8 (6) ns | 23.8± 5.4 (4) ns |
Rat platelets were isolated from whole blood. Anti-inflammatory drugs or antidepressants without (A) or with (B) Ca2+ were added and platelets were incubated at 37 °C for 10 or 60 min. Supernatants were collected and serotonin was analyzed by HPLC-EC. Values are given as mean ± SEM % of total control. The number of analyzed samples is given in parenthesis. Statistical analysis was performed by one-way ANOVA with a Fisher LSD posthoc test.
*
p < 0.05
**
p < 0.01
***
p < 0.001; ns, not significant