Table 4.
BDNF release by anti-inflammatory agents and antidepressants.
| A | ||
|---|---|---|
| 10 min | 60 min | |
| control | 13.2 ± 3.1 (12)− | 15.9 ± 3.0 (12)− |
|
| ||
| citalopram | 10.9 ± 4.0 (8) ns | 18.4 ± 1.9 (6) ns |
|
| ||
| ibuprofen | 16.0 ± 5.4 (6) ns | 18.7 ± 6.3 (7) ns |
|
| ||
| indomethacin | 18.9 ± 3.9 (8) ns | 21.6 ± 6.0 (8) ns |
|
| ||
| paroxetine | 17.1 ± 4.3 (9) ns | 20.2 ± 2.9 (7) ns |
|
| ||
| sertraline | 13.4 ± 2.8 (8) ns | 25.4 ± 5.8 (7) ns |
| B | ||
|---|---|---|
| 10 min | 60 min | |
| control + Ca2+ | 72.2±10.8 (9)− | 95.2±12.2 (9)− |
|
| ||
| citalopram + Ca2+ | 67.3±7.7 (6) ns | 95.3±14.5 (5) ns |
|
| ||
| ibuprofen + Ca2+ | 43.8±16.3 (5)* | 57.2±21.3 (5)** |
|
| ||
| indomethacin + Ca2+ | 76.6±13.7 (6) ns | 88.5± 17.6 (6) ns |
|
| ||
| paroxetine + Ca2+ | 58.9±20.2 (6) ns | 92.0 ±24.8 (4) ns |
|
| ||
| sertraline + Ca2+ | 77.8 ±16.4 (6) ns | 85.7 ±17.9 (4) ns |
Platelets were isolated from rat blood. Anti-inflammatory drugs or antidepressants without (A) or with (B) Ca2+ were added and platelets were incubated at 37 °C for 10 or 60 min. Supernatants were collected and BDNF was analyzed by ELISA. Values are given as mean ± SEM % of total. The number of analyzed slices is given in parenthesis. Statistical analysis was performed by one-way ANOVA with a Fisher LSD post-hoc test.
*
p < 0.05
**
p < 0.01; ns, not significant