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. 2014 Oct 29;121(2):331–339. doi: 10.1007/s11060-014-1636-6

Table 2.

Summary of multivariate CoxPH results with adjustment for KPS, age and extent of resection

Type Parameters considered Time point OS PFS
p value HR p value HR
Lesion size VolCEL (cc) BL 0.315 0.95 [0.87 1.05] 0.900 0.99 [0.92 1.08]
2mos 0.301 1.23 [0.83 1.81] 0.201 1.26 [0.89 1.79]
VolT2L (cc) BL 0.431 0.99 [0.98 1.01] 0.837 1.00 [0.99 1.15]
2mos 0.326 1.03 [0.97 1.10] 0.421 1.02 [0.97 1.07]

Histogram—

2-mixture normal fitting

 ADCL BL 0.91 1.01 [0.80 1.29] 0.75 0.95 [0.79 1.18]

Histogram—Percentiles in

T2L

ADC10%

(μm2/s/100)

 BL 0.116 0.77 [0.55 1.07] 0.032* 0.69 [0.50 0.97]
1mos 0.188 0.54 [0.21 1.36] 0.014* 0.39 [0.18 0.83]
2mos 0.001* 0.11 [0.03 0.41] 0.007* 0.31 [0.13 0.72]
4mos 0.005* 0.43 [0.23 0.78] 0.024* 0.54 [0.32 0.92]
ADC50% 4mos 0.011* 0.61 [0.42 0.89] 0.045* 0.73 [0.54 0.99]
Traditional fDM in T2L

VolΔADC<−250

(cc)

 BL-1mos 0.927 0.99 [0.82 1.20] 0.963 1.00 [0.84 1.20]
BL-2mos 0.552 1.13 [0.75 1.70] 0.603 1.09 [0.78 1.54]
Graded fDM in T2L Vol250<ΔADC<−180 BL-1mos 0.489 0.486 [0.06 3.76] 0.577 0.63 [0.13 3.16]
BL-2mos 0.347 2.36 [0.39 14.19] 0.481 1.65 [0.41 6.71]

*p < 0.05