Table 1.
Patients baseline characteristics (safety set)
| Etifoxine (n = 100) | Alprazolam (n = 101) | Total (n = 201) | |
|---|---|---|---|
| Female (%) | 76.0 | 70.3 | 73.1 |
| Age; mean (SD) [min–max] | 40.0 (11.8) [18–62] | 38.9 (12.8) [18–64] | 39.4 (12.3) [18–64] |
| Weight; mean (SD) [min–max] | 80.7 (19.4) [50–133] | 76.4 (18.4) [46–133] | 78.5 (19.0) [46–133] |
| Main stressor (%) | |||
| Family/love life | 39.0 | 38.6 | 38.8 |
| Work/school | 34.0 | 41.6 | 37.8 |
| Finance | 12.0 | 12.9 | 12.4 |
| Other | 15.0 | 6.9 | 10.9 |
| HAM-A total score; mean (SD) [min–max] | 29.3 (5.9) [20–46] | 30.5 (7.2) [20–55] | 29.9 (6.6) [20–55] |
| MADRS score; mean (SD) | 12.4 (4.3) | 12.4 (4.9) | 12.4 (4.6) |
| CGI severity score; mean (SD) | 3.9 (1.0) (n = 98) | 3.8 (1.1) (n = 98) | 3.8 (1.0) (n = 196) |
| SDS scores; mean (SD) | |||
| Work/schoola | 5.5 (2.2) (n = 84) | 6.3 (2.0) (n = 84) | 5.9 (2.1) (n = 168) |
| Social life | 5.9 (2.5) | 6.3 (2.0) | 6.1 (2.3) |
| Family life | 5.8 (2.3) | 6.2 (2.3) | 6.0 (2.3) |
CGI Clinical Global Impression Scale, HAM-A Hamilton Anxiety Rating Scale, MADRS Montgomery–Åsberg Depression Rating Scale, SD standard deviation, SDS Sheehan Disability Scale
aSubgroup of patients who worked/studied during the week preceding the study entry