Table 3. Kaplan-Meier analysis of survival by baseline characteristics.
| Characteristic | Survival, months† |
|||
|---|---|---|---|---|
| N | Median | 95% CI | P value | |
| All | 606 | 9.6 | 9.0-11.1 | NA |
| ECOG performance status | 0.009i | |||
| 0 | 168 | 11.2 | 9.1-13.1 | |
| 1 | 72 | 8.1 | 6.4-11.0 | |
| 2 | 14 | 6 | 2.3-12.2 | |
| 3 | 3 | 5 | 1.3-11.0 | |
| Extra-hepatic metastases | <0.001 | |||
| No | 393 | 12.1 | 10.8-13.6 | |
| Yes | 213 | 7.4 | 6.1-8.5 | |
| Primary tumor in situ | 0.016 | |||
| No | 522 | 10 | 9.1-11.8 | |
| Yes | 78 | 8.1 | 6.2-10.4 | |
| Ascites | <0.001ii | |||
| No | 563 | 10 | 9.2-11.8 | |
| Yes (controlled) | 5 | 2.4 | 0.7-22.9 | |
| Yes (uncontrolled) | 23 | 5.5 | 3.6-7.4 | |
| Prior lines of chemotherapy | <0.001 | |||
| RE 2nd-line | 206 | 13 | 10.5-14.6 | |
| RE 3rd-line | 184 | 9 | 7.8-11.0 | |
| RE 4th-line + | 158 | 8.1 | 6.4-9.3 | |
| RE 1st-line | 0.041 | |||
| All | 35 | 13.5 | 7.2-17.1 | |
| <75 years | 17 | 25.2 | 9.3-36.5 | |
| ≥75 years | 18 | 11.9 | 4.0-15.6 | |
| Number of 90Y-RE procedures | 0.005iii | |||
| 1 | 301 | 8.9 | 7.7-10.8 | |
| 2 | 264 | 9.6 | 8.6-11.2 | |
| 3 | 29 | 17.7 | 11.2-23.7 | |
| 4 | 10 | 19 | 9.3-25.4 | |
| 5 | 2 | 28.1 | 26.4-29.8 | |
| 1st to 2nd 90Y-RE procedure >90 days | <0.001 | |||
| No | 58 | 18.3 | 15.8-23.1 | |
| Yes | 246 | 9.2 | 8.1-9.9 | |
| Tumor-to-target liver involvement | <0.001 | |||
| <25% | 388 | 12.8 | 10.8-13.6 | |
| 25-50% | 148 | 6.5 | 5.7-8.1 | |
| >50% | 22 | 6 | 3.6-9.1 | |
| Carcinoembryonic antigen | <0.001 | |||
| < median | 215 | 13.6 | 12.2-16.3 | |
| ≥ median | 215 | 7.4 | 6.6-8.5 | |
| Total bilirubin, CTC grade | <0.001 | |||
| 0 | 556 | 10.4 | 9.3-11.9 | |
| ≥1 | 37 | 3.8 | 2.5-7.4 | |
| Albumin, CTC grade | <0.001 | |||
| 0 | 392 | 13 | 11.6-13.9 | |
| ≥1 | 199 | 6.3 | 5.4-7.1 | |
| Alkaline phosphatase, CTC grade | <0.001 | |||
| 0 | 241 | 15.7 | 13.9-17.7 | |
| ≥1 | 351 | 7.1 | 6.3-8.1 | |
| Aspartate aminotransferase, CTC grade | <0.001 | |||
| 0 | 296 | 13.9 | 12.2-15.6 | |
| ≥1 | 294 | 7.2 | 6.3-8.7 | |
| Creatinine, CTC grade | 0.041 | |||
| 0 | 569 | 9.6 | 9.0-11.2 | |
| ≥1 | 26 | 7.1 | 4.7-12.2 | |
| Hemoglobin, CTC grade | <0.001 | |||
| 0 | 356 | 12.2 | 10.6-13.6 | |
| ≥1 | 238 | 7.6 | 6.4-9.0 | |
P values for continuous variables by one-way ANOVA; P values for dichotomous variables by Fisher’s exact test, and P values for nominal categorical variables by Chi-Square general association test. †, median survival calculated by Kaplan-Meier analysis; i, P value: ECOG ps 0 vs. 1 vs. 2-3; ii, P value: ascites (not controlled) vs. ascites (controlled) or none; iii, P value: RE procedures 1 vs. 2 vs. 3-5. CI, confidence interval; NA, not applicable.