Table 2.
Comparisons of before versus after mean (sd) measures for each of the three groups and univariate comparison of the three groups at each time point (n=50 in each group)
| Measure | time point | pre- versus post-treatment comparison | comparison of 3 groups | ||||
|---|---|---|---|---|---|---|---|
| olanzapine | quetiapine | aripiprazole | statisticd | p | |||
| fasting blood glucose |
before treatment | 4.87(0.99) | 4.62(1.00) | 4.65(1.14) | χ2=2.93 | 0.232 | |
| after treatment | 5.49(1.51)a | 4.59(0.79) | 4.74(1.74) | χ2=30.39 | <0.001 | ||
| triglyceride | before treatment | 1.15(0.63) | 0.94(0.53) | 1.05(0.53) | χ2=5.33 | 0.070 | |
| after treatment | 1.95(1.50)a | 1.70(1.72)a | 1.26(0.80) | χ2=8.82 | 0.012 | ||
| total cholesterol | before treatment | 4.57(1.23) | 4.16(1.17) | 4.11(0.96) | χ2=5.13 | 0.077 | |
| after treatment | 4.72(1.12)b | 4.49(1.25) | 4.11(1.04)b | F=3.72 | 0.027 | ||
| low-density lipoprotein |
before treatment | 3.15(1.09) | 3.03(1.01) | 2.93(0.80) | χ2=0.67 | 0.716 | |
| after treatment | 3.23(0.78)c | 3.19(0.80) | 2.85(0.83)b | χ2=5.21 | 0.074 | ||
| high-density lipoprotein |
before treatment | 1.45(0.42) | 1.32(0.36) | 1.32(0.33) | χ2=3.30 | 0.192 | |
| after treatment | 1.19(0.31)a | 1.19(0.32)a | 1.30(0.31) | F=2.16 | 0.119 | ||
| PANSS total score |
before treatment | 89.08(14.24) | 88.84(15.19) | 93.68(12.76) | F=1.87 | 0.158 | |
| after treatment | 53.10(15.86)a | 54.44(15.09)a, b | 54.64(16.29)a, b | χ2=0.24 | 0.886 | ||
| PANSS positive symptoms score |
before treatment | 22.80(5.97) | 20.82(8.2) | 22.58(5.69) | F=1.04 | 0.357 | |
| after treatment | 12.70(5.55)a | 12.18(5.19)a | 12.48(4.79)a | χ2=0.30 | 0.863 | ||
| PANSS negative symptom score |
before treatment | 26.12(7.86) | 28.72(7.25) | 29.12(6.16) | χ2=4.85 | 0.089 | |
| after treatment | 15.08(7.46)a | 16.78(7.20)a | 16.48(7.62)a | χ2=1.42 | 0.492 | ||
| PANSS general psychopathology score |
before treatment | 40.12(5.94) | 39.76(6.11) | 42.10(6.01) | χ2=4.49 | 0.106 | |
| after treatment | 25.34(5.55)a | 25.94(4.68)a, b | 25.36(5.61)a | χ2=4.49 | 0.106 | ||
PANSS, Positive and Negative Syndrome Scale
abefore v. after comparison statistically significant at p<0.01 level
bcomparisons of before-versus after values using paired t-test; all other comparisons used Wilcoxon signed-rank test
cbefore v. after comparison statistically significant at p<0.05 level
dcomparison across the 3 groups uses univariate ANOVA for normally distributed variables and Kruskal-Wallis test for non-normal variables