Fig. 4.
Differential stabilization of the compact conformation induced by inhX and pep15. (A,D) Representative class averages from the γ-secretase–inhX and γ-secretase–pep15 datasets, respectively. (B,E) 3D averages and representative RCT structures from the γ-secretase–inhX and γ-secretase–pep15 datasets, respectively, displayed from the side as the untreated γ-secretase structures (Fig. 3B–G). (C,F) Length distribution of the different γ-secretase–inhX and γ-secretase–pep15 structures, respectively, based on measurement along their major axis.