Table 2.

Effects of cholesterol diet on animal weight.

Group	7 months	14 months	20 months
WT	31.7 ± 0.6 (5) -	37.9 ± 1.6 (5) -	35.7 ± 0.7 (5) -
WT + Chol	40.9 ± 0.6 (5) ***	41.1 ± 2.0 (5) ns	46.4 ± 0.9 (5) ***
3xTg-AD	33.3 ± 1.2 (5) ns	38.7 ± 1.0 (5) ns	34.6 ± 0.6 (5) ns
3xTg-AD + Chol	34.8 ± 1.1 (5) §§§	33.0 ± 2.0 (5) § #	0/10 survived

Cholesterol diet causes significant weight gain in wildtype (WT) but not in triple-transgenic Alzheimer’s disease (3xTg-AD) mice at 7 months.WT (129/C57BL6) and 3xTg-AD (B6;129-Psen1^tm1MpmTg(APPSwe, tauB301L)1Lfa/J) mice were fed a 5% cholesterol diet (Chol) from age 2 months and onwards. Animalweights were taken following behavioral testing and immediately prior to anesthesia and organ collection. Values represent mean weight in grams ± SEM. The number in parentheses provides the number of animals tested. Statistical analysis was performed using a one-way ANOVA and Fisher’s LSD posthoc test. Symbols indicate the significant difference between groups compared toWT(*p < 0.05, ***p < 0.001, ns not significant), WT + cholesterol (§p < 0.05, §§§ p < 0.001) or 3xTg-AD (#p < 0.05).