Table 3.
Group | 7 months | 14 months | 20 months |
---|---|---|---|
WT | 5905 ± 1080 (5) - | 4810 ± 986 (5) - | 4026 ± 1869 (5) - |
WT + Chol | 5748 ± 935 (5) ns | 1795 ± 867 (5) * | 3933 ± 1608 (5) ns |
3xTg-AD | 6145 ± 520 (5) ns | 4226 ± 1061 (5) ns | 7185 ± 804 (5) ns |
3xTg-AD + Chol | 4833 ± 1493 (5) ns | 7195 ± 778 (5) §§§ # | 0/10 survived |
Plasma was collected following behavioral testing and immediately prior to anesthesia and organ collection. Values representmean plasma corticosterone in pg/ml ± SEM. The number in parentheses indicates the number of animals tested in each group. Statistical analysis was performed using a one-way ANOVA with a Fisher’s LSD posthoc test. Symbols indicate the significant difference between groups compared toWT (*p < 0.05, ns not significant),WT + cholesterol (Chol) (§§§ p < 0.001) or 3xTg-AD (#p < 0.05).