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Summary of outcomes or pathologies for investigated mouse models.
| Pathology/outcome | Measure | APPSwDI | WT + CHOL | 3xTg-AD | 3xTg-AD + CHOL |
|---|---|---|---|---|---|
| Diet | Weight | NA | ↑ ↑ ↑ | = | (↓) |
| Cholesterol diet | Plasma cholesterol | NA | ↑ ↑ | ↑ | ↑ |
| Cognitive function | Maze | NA | ↓ | ↓ ↓ | (↑) |
| Stress | Corticosterone | NA | ↓ | = | ↑ |
| AD-like | Aβ, PHF-tau | Aβ ↑↑↑ | - | Aβ ↑↑ | Aβ ↑ |
| Tau ↑↑ | Tau ↑ | ||||
| Neuroinflammation | GFAP, Iba1, C1q | ↑ ↑ ↑ | ↑ | ↑ ↑ | = |
| C1q ↑ | |||||
| BBB disruption | Mo IgG, ApoE | ↑ ↑ ↑ | ↑ | (↑) | = |
| Vessel staining | Collagen IV, tTG-2 | ↓ | ↑ ↑ | = | ↑ |
