Table 4.
Correlation Coefficients for Change in SkM HSP70 Levels Over the 4-Year Study and Individual Rate of Change in Insulin Sensitivity Biomarkers, With Models Additionally Adjusted for Baseline Metabolic Syndrome-Related Parameters
| Insulin (U/L/y) | HOMA (AU/y) | Glucose (mg/dL/y) | |
|---|---|---|---|
| % Change in SkM HSP70 | R = −.43 | R = −.36 | R = −.25 |
| p = .007 | p = .023 | p = .12 | |
| % Change in SkM HSP70; adjusted for age | R = −.50 | R = −.43 | R = −.26 |
| p = .001 | p = .006 | p = .12 | |
| % Change in SkM HSP70; adjusted for age, waist | R = −.49 | R = −.43 | R = −.27 |
| p = .002 | p = .008 | p = .11 | |
| % Change in SkM HSP70; adjusted for age, waist, TG | R = −.49 | R = −.43 | R = −.26 |
| p = .002 | p = .001 | p = .12 | |
| % Change in SkM HSP70; adjusted for age, waist, TG, HDL-C | R = −.46 | R = −.40 | R = −.28 |
| p = .006 | p = .016 | p = .10 | |
| % Change in SkM HSP70; adjusted for age, waist, TG, HDL-C, SBP | R = −.44 | R = −.37 | R = −.23 |
| p = .02 | p = .05 | p = .23 |
Notes: HDL-C = high-density lipoprotein cholesterol; HOMA = homeostasis model assessment; HSP70 = heat shock protein 70; SBP = systolic blood pressure; SkM = skeletal muscle; TG = triglyceride.