Figure 8. Temporal shift in the relative abundance of species-level OTUs in subjects with and without dental caries experience.

Only seven OTUs in which dental caries experience had a significant effect on their relative abundance (P < 0.05, two-way ANOVA) are shown. **P < 0.01, *P < 0.05, using post-hoc Student's t-test analyzed per sampling time. The error bars indicate standard error. CE, caries-experienced subjects; CF, caries-free subjects.