Table 2. List of coevolving amino acid residues both at the intra- and inter-protein levels found for Wheat dwarf virus.

Intra-protein or inter-protein		Group	Number of amino acids	Number of isolates	Amino acid sites
WDV-wheat-specific group	CP	1	2	184	A132, T146—*
	MP	1	4	184	D13—, I21, C61, L81
	Rep	12	17	184	A2, T6, T24, Y29—, A30, L31, D32—, N39, A48—, I94—, V115—, N157—, D2800, T335—, S343, E345, D3460
	Rep A	2	8	184	T67—, G76—,C79—,G93—, I94—,T102—, C109—, T233
	CP/MP	0	0	184	NA
	CP/Rep	6	7	184	M15, P108, F109—, A132, T146—, T178—, T240— [A2, A6, T24, Y29—, D32—, N39, A480, A1150, N157—, D2800, S343]
	CP/Rep A	6	7	184	M15, P108, F109—, A132, T146—, T178—, T240— [A2, A6, T24, Y29—, D32—, N39, A480, N157—, Q226—]
	MP/Rep	0	0	184	NA
	MP/Rep A	0	0	184	NA
	Rep/Rep A	14	19	184	A2, A6, T24, Y29—, A30, L31, D32—, L38, N39, K40, A480, G94—, A115—, N157—, D2800, T335—, S343, E345, D3460 [A2, A6, T24, Y29—, A30, L31, D32—, L38, N39, K40, A480, G94, A115—, N157—, Q226]
WDV-barley specific group	CP	2	6	24	K33, T137, N190, I191—, V192, I233—
	MP	0	0	24	NA
	Rep	2	7	24	D32, I80, G81, N83, F89—, V124, S183
	Rep A	1	6	24	D32, I80, G81, N83, F89—, S183
	CP/MP	0	0	24	NA
	CP/Rep	0	0	24	NA
	CP/Rep A	0	0	24	NA
	MP/Rep	0	0	24	NA
	MP/Rep A	0	0	24	NA
	Rep/Rep A	0	0	24	NA
ODV	CP	0	0	1	NA
	MP	0	0	1	NA
	Rep	0	0	1	NA
	Rep A	0	0	1	NA
	CP/MP	0	0	1	NA
	CP/Rep	0	0	1	NA
	Rep A	0	0	1	NA
	MP/Rep	0	0	1	NA
	MP/Rep A	0	0	1	NA
	Rep/Rep A	0	0	1	NA

*^— and ⁰ in the upper right corner of the amino acid means negative and neutral selection, respectively. The sites in the brace are amino acids involved in inter-protein coevolution.

NA: not available.