Fig. 2.

Inhibitory effect of propantheline on tension development in the isolated ileum of rat treated with 5-HT (2 μM), acetylcholine (ACh, 500 nM) and electrical field stimulation (EFS: 6 V, 50 Hz, 1 s duration). Each data point is mean ± SEM (n=6). Ordinant scales: spasm remaining as a % of the contraction prior to propantheline addition. Abscissa scales: log₁₀ concentration of propantheline. Each point is mean and the vertical lines show the SEM. EFS-1=initial contractile response. EFS-2=secondary contractile response. Stars show significant differences at corresponding propantheline concentration with 5-HT. *P<0.05, **P<0.01, ***P<0.001 (Student's t-test).