Fig. 4.

TBARS formation induced by amodiaquine and the preventive role of taurine and/or N-acetyl cysteine. BHP: 1-bromoheptane. Isolated rat hepatocytes (10⁶ cells/mL) were incubated at 37°C in rotating round bottom flasks with 95% O₂ and 5% CO₂ in Krebs-Henseleit buffer (pH 7.4). Data are shown as Mean ± SEM for three independent experiments as measured after 120 min of incubation. ^aDifferent from control group (n=3, ANOVA, P<0.05). ^bDifferent from amodiaquine-treated group (n=3, ANOVA, P<0.05). ^cDifferent from amodiaquine-treated group (n=3, ANOVA, P<0.05). ^dDifferent from amodiaquine-treated groups which were depleted of glutathione (BHP-treated) (n=3, ANOVA, P<0.05).