Fig. 6.

Mitochondrial depolarization induced by amodiaquine and the role of NAC and/or taurine. Data are given as Mean ± SEM for at least three separate experiments as assessed 60 min after incubation. Isolated rat hepatocytes (10⁶ cells/mL) were incubated at 37°C in rotating round bottom flasks with 95% O₂ and 5% CO₂ in Krebs-Henseleit buffer (pH 7.4). ^a,bDifferent from control groups (n=3, ANOVA, P<0.05). ^cDifferent from amodiaquine-treated hepatocytes (n=3, ANOVA, P<0.05). ^dDifferent from amodiaquine-treated cells which were glutathione-depleted (n=3, ANOVA, P<0.05).