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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Labelled Comp Radiopharm. 2014 Oct 31;57(13):705–709. doi: 10.1002/jlcr.3239

Scheme 1.

Scheme 1

Synthesis of ATPFU, hydroxyl and tosyl analogues. i) DMF/POCl3, rt, 72%; ii) CF3CH2NHNH2, EtOH, Et3N, -78 °C, 64%; iii) (1R,5S)8-oxa-3-azabicyclo[3.2.1]octane hydrochloride, Et3N, rt, 60%; iv) triphosgene, CH2Cl2, rt; 84%; v) Na2CO3, acetonitrile, Pd(PPh3)4, 90 °C, 64%; vi) TsCl, CH2Cl2, Et3N, rt, 78%.