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. 2015 Jan 21;8:37. doi: 10.1186/s13071-015-0650-7

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© Zhang et al.; licensee BioMed central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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S. japonicum infection results in an exacerbated liver granulomatous inflammation in AQP4 KO mice. At 0,3, 5,8 weeks post-infection, four AQP4 WT or KO mice were randomly chosen and sacrificed. Liver sections were stained with HE for microscopic examination. (A) Histopathology in the livers (magnification: 100×). Results are representative of two independent experiments. (B) Sizes of the granulomas were measured by computer-assisted morphometric analysis. (C) Absolute numbers of neutrophils, eosinophils, lymphocytes and macrophages in the granulomas. Values are given as mean ± SD of 8 AQP4 WT or KO mice from two independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.