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. 2015 Jan 21;8:37. doi: 10.1186/s13071-015-0650-7

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© Zhang et al.; licensee BioMed central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Th1 cell responses are decreased in S. japonicum- infected AQP4 KO mice . (A) At 0, 3, 5, 8 weeks post-infection, the generation of IFN-γ producing-CD3⁺CD4⁺ cells in the spleen, lymph nodes and liver of AQP4 WT and KO mice was determined by intracellular staining and FCM. (B) The proportion (gated on CD3⁺ cells) of Th1 cells in mouse spleen, lymph nodes and livers. Representative histograms obtained by FCM analysis (C) of mean fluorescence intensity (MFI) of IFN-γ expression in Th1 cells (D). (E) The absolute number of Th1 cells in mouse spleen, lymph nodes and livers. Data represent means ± SD of 8 mice from two independent experiments. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. AQP4 WT-0 W; ^$P < 0.05, ^$$P < 0.01, ^$$$P < 0.001 vs. AQP4 KO-0 W; *P < 0.05, **P < 0.01, ***P < 0.001 Th1 cells from AQP4 KO mice vs. from AQP4 WT mice at 0, 3, 5, 8 weeks post-infection.