Table 2.
Logistic regression, odds of cancer among women with BIRADS 4 mammograms, N = 464 a
| Age-adjusted | Multivariate b | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P -value | OR | 95% CI | P -value | |
| SNP panel RR, log continuous scale | 2.15 | 1.04 to 2.43 | 0.038 | 2.30 | 1.06 to 4.99 | 0.035 |
| SNP panel RR, categories | ||||||
| <1.00 | 1.00 | Reference | ||||
| 1.01 to 1.49 | 1.09 | 0.59 to 2.02 | 0.788 | |||
| ≥1.50 | 1.60 | 0.84 to 3.04 | 0.149 | |||
| Gail RR, log continuous scale | 1.11 | 0.69 to 1.78 | 0.660 | |||
| Gail absolute 5-yr risk, % | ||||||
| <1.67 | 1.00 | Reference | ||||
| ≥1.67 | 1.09 | 0.60 to 1.98 | 0.778 | |||
| Age, log continuous scale | 1.05 | 1.03 to 1.07 | <0.001 | 1.05 | 1.03 to 1.08 | <0.001 |
| Race/ethnicity | ||||||
| White | 1.00 | Reference | 1.00 | Reference | ||
| African American/black | 0.66 | 0.37 to 1.19 | 0.170 | 0.53 | 0.26 to 1.06 | 0.071 |
| Other | 0.86 | 0.33 to 2.20 | 0.748 | 0.81 | 0.30 to 2.23 | 0.689 |
| Age at menarche, yr | ||||||
| <11 | 1.44 | 0.65 to 3.21 | 0.368 | 1.33 | 0.57 to 3.09 | 0.510 |
| 12 to 13 | 1.67 | 0.85 to 3.30 | 0.139 | 1.50 | 0.73 to 3.06 | 0.266 |
| ≥14 | 1.00 | Reference | 1.00 | Reference | ||
| Unknown | 0.77 | 0.29 to 2.07 | 0.608 | 0.83 | 0.28 to 2.41 | 0.729 |
| Age at first live birth, yr | ||||||
| <30 | 1.00 | Reference | 1.00 | Reference | ||
| ≥30 | 1.58 | 0.81 to 3.08 | 0.183 | 1.37 | 0.66 to 2.87 | 0.400 |
| Nulliparous | 1.09 | 0.58 to 2.06 | 0.780 | 1.06 | 0.54 to 2.08 | 0.867 |
| Missing data | 1.60 | 0.17 to 15.0 | 0.680 | 2.26 | 0.22 to 23.6 | 0.497 |
| First-degree relatives with breast cancer, n | 1.48 | 0.86 to 2.57 | 0.160 | 1.62 | 0.90 to 2.90 | 0.106 |
| Prior breast biopsy | 0.73 | 0.43 to 1.24 | 0.242 | 0.82 | 0.47 to 1.46 | 0.508 |
| Prior atypical hyperplasia | 0.41 | 0.09 to 1.86 | 0.247 | 0.51 | 0.10 to 2.54 | 0.410 |
| BMI, kg/m2, mean ± SD | ||||||
| <25 | 1.00 | Reference | 1.00 | Reference | ||
| 25 to 29.9 | 1.68 | 0.81 to 3.47 | 0.161 | 1.86 | 0.86 to 4.05 | 0.116 |
| ≥30 | 1.94 | 0.99 to 3.81 | 0.054 | 2.20 | 1.05 to 4.58 | 0.036 |
| Missing data | 1.85 | 0.87 to 3.93 | 0.111 | 1.80 | 0.81 to 3.99 | 0.147 |
aBI-RADS, Breast Imaging-Reporting and Data System; BMI, Body mass index; CI, Confidence interval; OR, Odds ratio; RR, Relative risk; SD, Standard deviation; SNP, Single-nucleotide polymorphism. bMultivariate model includes log SNP RR, age, BMI, race/ethnicity, age at menarche, age of first birth, family history of breast cancer, breast biopsy and atypical hyperplasia.