Table 1.
Demographic and clinical characteristics of HCV-infected patients and healthy control subjects
| Variable | Chronic HCV | Liver cirrhosis | HCC | Healthy control | pvalue a |
|---|---|---|---|---|---|
| Age (yrs) | 50.9 ± 14.98 | 58.30 ± 11.86 | 63.23 ± 10.70 | 30.79 ± 8.90 | <0.0001 |
| Male gender (%) | 233 (51.4%) | 61 (50%) | 12 (46.2%) | 550 (96.7%) | <0.0001 |
| BMI (Kg/m2)* | 29.2 (25.67-33.39) | 30.06 (26.22-33.06) | 25.99 (21.89-31.39) | 0.804 | |
| Platelets (109/L)* | 230 (178.75-282.25) | 163.5 (108.50-205.50) | 104.00 (51.50-139.00) | <0.0001 | |
| ALT (U/L)** | 68.973 ± 57.99 | 78.66 ± 50.76 | 114.33 ± 31.78 | 0.738 | |
| AST (U/L)** | 43.54 ± 33.30 | 72.67 ± 48.81 | 91.33 ± 24.58 | <0.0001 | |
| ALP (U/L)** | 113.37 ± 78.91 | 133.66 ± 90.04 | 147.00 ± 96.70 | 0.072 | |
| DM2 | |||||
| Overall (30.8%) | 134 (72.4%) | 44 (23.8%) | 7 (3.8%) | 0.693 | |
| HCV genotypes | |||||
| 4 (357) | 249 (70%) | 86 (24%) | 22 (6%) | <0.0001 | |
| 1 (148) | 115(77.7%) | 30 (20.3%) | 3 (2%) | ||
| Others¶¶ (96) | 89 (92.7%) | 6 (6.3%) | 1 (1%) | ||
| HCV RNA (Log10)* | 5.85 (4.81-6.54) | 5.63 (4.86-6.32) | 5.98 (2.79-7.24) | 0.552 |
*Values are expressed as median interquartile range (25th - 75th), **Values are expressed as mean ± SD.
pa: nonparametric test and one way Anova for continuous data and Chi square test for categorical data.
¶¶ includes genotypes 2, 3 and untypable genotypes. Abbreviations: HCV hepatitis C virus, HCC hepatocellular carcinoma, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP Alkaline Phosphatase, BMI body mass index; DM2: diabetes mellitus.