Table 1.

Optimization of reaction conditions: multicomponent versus domino reaction.

Entry	TiCl4–M	THF (mL)	Acetone (mL)	CH2Cl2 (mL)	1 (Yield, %a)	2 (Yield, %a)
1	M = Zn	10	–	–	–	84b
2	M = Zn	10	0.37 (5 mmol)	–	66	11
3	M = Zn	–c	10	–	63	–
4	M = Zn	–c	1	5	70	–
5	M = Zn	–c	0.37 (5 mmol)	5	77	–
6	M = Mn	–c	0.37 (5 mmol)	5	45	–
7	M = Fe	–c	0.37 (5 mmol)	5	–	–
8	–	–c	0.37 (5 mmol)	5	–	–
9	M = Znd	–c	0.37 (5 mmol)	5	–	–

^aYield determined by ¹H NMR spectroscopy with acetophenone added as an internal standard to the crude reaction mixture after work-up. ^bData taken from [30]. ^cTHF was added dropwise diluted in a 80 wt % solution of t-BuOOH. ^dIn the absence of TiCl₄.