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. 2015 Jan 30;6:24. doi: 10.3389/fpls.2015.00024

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Copyright © 2015 Bruggeman, Raynaud, Benhamed and Delarue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified representation of sphingolipid metabolism in plants. The de novo biosynthesis of ceramides occurs in the endoplasmic reticulum and synthesis of more complex sphingolipids occurs in the Golgi. Sphingosine and phytosphingosine are both referred in the text as Long-chain Basis (LCB). Factors disrupted in LMM are indicated in red. AAL, Alternaria alternata f. sp. lycopersici; ACD5/11, Accelerated cell death 5/11, are a ceramide kinase and a ceramide-1-phosphate transporter, respectively; ERH1/IPCS2, Enhancing RPW8-mediated HR-like cell death 1/Inositolphosphoceramide synthase 2; FB1, Fumosin B1; LCB1/2a/2b, Long-chain base 1/2a/2b, are subunits which form the Serine palmitol-transferase; LOH1/2/2 Lag one homolog1/2/3, are ceramide synthases; MIPS1, Myo-inositol-1-phosphate synthase; PIS, Phosphatidylinositol synthase; SBH, Sphingoid base hydroxylase; SphK, Sphingosin kinase.