Table 2.

Suppressors of LMM.

Mutant	lmm supressed	Gene ID	Gene Product	Possible mechanism involved	References
act1	ssi2	At1g32200	Chloroplastic glycerol-3-phosphate acyltransferase	act1 mutant accumulates 18:1 fatty acid within the chloroplast, this could explain the suppression of ssi2 cell death	Kachroo et al., 2003
adr1	lsd1	At1g33560	CC-NBS-LRR immune receptor	ADR1 is a positive regulator of SA signaling	Bonardi et al., 2011; Roberts et al., 2013
adr1-l1	lsd1	At4g33300	CC-NBS-LRR immune receptor	ADR1-L1 is a positive regulator of SA signaling	Bonardi et al., 2011; Roberts et al., 2013
adr1-l2	lsd1	At5g04720	CC-NBS-LRR immune receptor	ADR1-L2 is a positive regulator of SA signaling	Bonardi et al., 2011; Roberts et al., 2013
edts5/ald1	edr2 agd2	At2g13810	Aminotransferase homologs to AGD2	Unknown	Nie et al., 2011
bzip10	lsd1	At4g02640	BZIP transcription factor	In wild-type plants, LSD1 retain BZIP10 in cytoplasm. In lsd1 mutants, BZIP10 translocate into nucleus to regulate expression of genes involved in lsd1 cell death	Kaminaka et al., 2006
caa39	flu	At5g02820	Subunit of the topoisomerase VI complex (TOP6A)	TOP6A binds to promoter of genes regulated by ROS signaling.	Simkova et al., 2012
cao	lsd1	At5g50920	Chaperone necessary for the assembly of the photosystem II antenna	A fully functional photosystem II is necessary for lesion formation in lsd1
crt1	ssi4	At4g36290	ATPase that interacts with diverse resistance proteins	Unknown	Kang et al., 2008
crt3	bir1	At1g08450	Calreticulin involved in the ER quality control	crt3 and erdj3b are characterized by a decrease of SOBIR1 accumulation	Sun et al., 2014
erdj3b	bir1	At3g62600	J domain protein involved in the ER quality control		Sun et al., 2014
ex1	flu	At4g33630	Chloroplastic protein with unknown molecular fucntion	EX1 and EX2 act together to integrate 1O2signal from chloroplasts and subsequently induce signaling responses that induce cell death in flu	Wagner et al., 2004; Lee et al., 2007b; Kim et al., 2012
ex2	flu	At1g27510	Chloroplastic protein with unknown molecular fucntion		Lee et al., 2007b; Kim et al., 2012
hpr1	edr1	At5g09860	Component of the THO/transcrtiption export complex required for mRNA export	A fully functional mRNA export machinery is necessary for cell death in edr1	Pan et al., 2012
laz1	acd11	At4g38360	Protein with a domain of unknown function (DUF300)	Unknown	Malinovsky et al., 2010
laz2	acd11	At1g77300	Histone lysine 36 methyl transferase	LAZ2 is necessary for the proper expression of LAZ5 which is then a positive mediator of acd11-dependent cell death	Palma et al., 2010
laz5	acd11	At5g44870	Putative TIR-NB-LRR R-protein	LAZ5 is A R-protein which could triggers cell death in the absence of ACD11	Palma et al., 2010
lol1	lsd1	At1g32540	Protein homologs to LSD1, with 3 zinc finger domains	LOL1 is and LSD1 have antagonistic effects on ROS homeostasis	Epple et al., 2003
mc1	lsd1	At1g02170	Type 1 metacaspase	Unknown	Coll et al., 2010
oxt6	cat2	At1g30460	Subunit of the CPSF complex involved in mRNA polyadenylation (CPSF30)	CPSF30 regulates positively the expression of a large number of genes involved immune responses	Bruggeman et al., 2014
	cpr5
	lsd1
	mips1
plp2	vad1	At2g26560	Lipid acyl hydrolase with wide substrate specificities	PLP2 could provide fatty acid precursors for the biosynthesis of oxylipins	La Camera et al., 2009
prl1	flu	At4g15900	Nuclear WD40 protein with unknown molecular function	PRL1 has a role in modeling 1O2-dependent signaling	Baruah et al., 2009
rar1	ssi4	At5g51700	Small protein with two zinc binding domains, involved in defense signaling	A disruption of RAR1 affects a multiple R gene-triggered responses	Zhou et al., 2008
rdc8	ssi2	At2g40690	Glycerol-3-phosphate deshydrogenase (GLY1)	Decrease in glycerol-3-phosphate pool	Kachroo et al., 2004
sdf2	bir1	At2g25110	Protein involved in the ER quality control	Same as crt3 suppressor	Sun et al., 2014
sfd4	ssi2	At4g30950	Fatty acid desaturase involved in the synthesis of polyunsaturated lipids	Decrease in plastid complex lipid species containing hexadecatrienoic acids	Nandi et al., 2003
sobir1	bir1	At2g31880	Receptor-like kinase	In absence of BIR1, SOBIR1 activates resistance signaling pathways	Gao et al., 2009
soldat8	flu	At2g36990	SIGMA6 (SIG6) factor of the plastid RNA polymerase	Disruption of SIG6 disturbs chloroplasts homeostasis that could acclimate plants and then suppress flu 1O2-mediated cell death	Coll et al., 2009
soldat10	flu	At2g03050	Plastidial protein related to the human mTERF	Same as soldat8	Meskauskiene et al., 2009
sr1-4D (gof)	edr2	At2g22300	Calmodulin-binding transcription factor	Probalby due to enhanced repression of genes involved in edr2 cell death	Nie et al., 2012
summ1	mkk1/mkk2	At4g08480	MAP kinase kinase kinase	In absence of MKK1/MKK2 or MPK4, SUMM1 triggers SUMM2-mediated immune responses	Kong et al., 2012
	mpk4
summ2	mkk1/mkk2	At1g12280	Putative NB-LRR R protein	In absence of MKK1/MKK2 or MPK4, SUMM2 activates resistance signaling pathways	Zhang et al., 2012
	mpk4
sup6	acd6	At5g20660	Putative Metalloprotease	Unknown	Lu et al., 2009
ulf3/hy1	flu	At2g26670	Heme oxygenase involved in biosynthesis of chromophore	Accumulation of heme in hy1 inhibits the Glu-tRNA enzyme conducing to a decrease in Pchlide content	Goslings et al., 2004