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. 2015 Jan 30;9:7. doi: 10.3389/fnbeh.2015.00007

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Copyright © 2015 López-Ramos, Guerra-Narbona and Delgado-García.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrophysiological properties of the three (MD-mPFC, CA1-mPFC, and Amyg-mPFC) synapses studied in alert behaving mice. Input-output curves (A–C), paired-pulse facilitation (D–F), which ratio between amplitudes was calculated through the formula [2nd/1st] × 100], and long-term potentiation (LTP; G–I) evoked at the three (MD-mPFC, CA1-mPFC, and Amyg-mPFC) synapses. The LTP was evoked by a high-frequency stimulation session presented at the indicated time (arrow). Note the different profiles of input-output curves, paired-pulse facilitation, and LTP evoked at the three synapses. Bs, baseline. Data are presented as mean ± SEM, n ≥ 8 animals/group. *p < 0.05; **p < 0.01; ***p < 0.001.