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. 2015 Jan 30;5:687. doi: 10.3389/fimmu.2014.00687

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Copyright © 2015 Pauza, Poonia, Li, Cairo and Chaudhry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Some of the known functions for human Vδ2 T cells that are related to HIV infection. Naïve Vδ2 T cells can be stimulated to produce Type 1 cytokines/chemokines for antiviral immunity (47) or display potent lytic effect function against tumor cells (82, 83) or infected cells (47). Vδ2 T cells also provide and receive costimulation from both NK cells (86) and dendritic cells (87). They display some similarity to T follicular helper cells required for B cell responses (85) and can function as antigen-presenting cells (84).