Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Stimulated Vδ2 T cells co-stimulate NK to increase tumor cell cytolysis. Activated Vδ2 T cells express 4-1BBL that binds 4-1BB on NK cells. The NKG2D receptor on NK is upregulated allowing stronger recognition of tumor cells expressing self-stress ligands ULBP or MIC A/B (86). HIV-mediated destruction of Vδ2 T cells will cripple the important mechanism for NK costimulation and reduce natural tumor surveillance.
