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Optimization of the reaction conditions for heterocycle 6a synthesis.
| Catalyst | Catalyst amount (% of the stoichiometric) | Product yield (%) |
| Sc(OTf)3 | 2 | 27 |
| Sc(OTf)3 | 5 | 62 |
| Sc(OTf)3 | 10 | 58 |
| Sc(OTf)3 | 15 | 38 |
| Yb(OTf)3 | 2 | 35 |
| Yb(OTf)3 | 5 | 66 |
| Yb(OTf)3 | 10 | 59 |
| Yb(OTf)3 | 15 | 42 |
| Al(O-iPr)3 | 10 | no product |
| Al(O-iPr)3 | 20 | 15 |
| HCl | 5 | no product (mixture resinification) |
| p-TsOH | 2 | no product (mixture resinification) |
