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. 2014 Dec 19;10:3073–3086. doi: 10.3762/bjoc.10.324

Figure 2.

Figure 2

Inhibition of sialylation of LN by compounds 13 and 18. A: N-acetyllactosamine (LN, 1 mM), 3’-sialyllactose (SL, 1 mM) and TcTS were incubated for 15 min at 25 °C. B: The same as A, in the presence of 13 (1 mM) as inhibitor. C: The same as A, in the presence of 18 (1 mM) as inhibitor. The incubation mixtures were analyzed by HPAEC using a CarboPac PA-10 ion exchange analytical column eluted with a linear gradient over 30 min from 20 to 200 mM NaAcO in 100 mM NaOH at a flow rate of 0.9 mL/min. L: lactose; SA: sialic acid; SLN: sialyl N-acetyllactosamine; S13: monosialyl compound 13.