Table 1.
Baseline patient characteristics and FISH results
| Variable | Whole cohort | Patients receiving RFA |
|---|---|---|
|
| ||
| No. of subjects | 181 | 66 |
|
| ||
| Age, yrs | 66.0 ± 9.5 | 65.6 ± 8.7 |
|
| ||
| Sex, N (%) | ||
| Men | 145 (80) | 60 (91) |
| Women | 36 (20) | 6 (9) |
|
| ||
| Barrett length, cm ¶ | 4 (2-7) | 6 (4-8) |
|
| ||
| Baseline histology | ||
| HGD, N (%) | 147 (81) | 61 (92) |
| IMC, N (%) | 34 (19) | 5 (8) |
|
| ||
| Body mass index, mean (SD), kg/m2 | 30.0 ± 4.5 | 30.7 ± 4.5 |
|
| ||
| Smoking, N (%) | 13 (7) | 6 (9) |
|
| ||
| Alcohol use, N (%) † | 31 (17) | 10 (15) |
|
| ||
| Normal FISH result, N (%) ‡ | 69 (38) | 17 (26) |
|
| ||
| P16 loss, N (%) | 52 (29) | 22 (33) |
|
| ||
| Single locus gain, N (%) | 35 (19) | 13 (20) |
|
| ||
| Multiple gains, N (%) | 80 (44) | 37 (56) |
FISH, fluorescence in situ hybridization; SD, standard deviation; HGD, high-grade dysplasia; IMC, intramucosal carcinoma.
*
Plus-minus values are means ± SD.
¶
Data are shown as median (IQR).
†
Alcohol use was defined as a self-reported intake of more than two units a day.
‡
The expected normal signal pattern for all probes is two signals per nucleus. If the percentage of nuclei showing abnormal signal patterns is less than the cut-off value for all possible abnormalities (i.e. P16 loss, single locus gain, multiple gains), the result is designated as normal.